Consider hiring your spouse and possibly establishing a medical reimbursement plan (under IRC Section 105) to pay medical expenses. Paying medical expenses under this type of plan allows you to get a full tax deduction on your business return lowering your business income, as opposed to an itemized deduction which is subject to limitations.
Sally and John have $5,000 of out-of-pocket medical expenses they are not able to deduct because their medical expenses do not exceed 7.5% of their Adjusted Gross Income. Sally has a consulting business and hires John to keep track of her books and establishes a medical reimbursement plan. John is reimbursed for the $5,000 of out-of-pocket medical expenses and Sally receives a $5,000 business deduction. Since Sally and John are in the 25% tax bracket, they will save $1,250 in taxes.
If you are in a combined (federal and state) tax bracket of 35%, you could reduce your taxes up to $350 for every $1,000 of medical expenses reimbursed through this plan.